Optimization of medium composition to enhance cordycepin synthesis and stress tolerance in engineered pichia pastoris
Cordycepin is a bioactive compound with extensive pharmacological activities and potential medical applications. This study focuses on the optimization of cordycepin production in an engineered Pichia pastoris strain, THP-292, constructed in our laboratory. By screening optimal culture media and supplementing with adenine and fucoidan, we aimed to improve cordycepin synthesis and enhance stress tolerance.