Potato crop is one of the most important vegetable crops. Potato tubers are the economic part used in human nutrition and at the same time the part used for multiplying. Tubers enter obligatory dormancy when they mature. The dormancy of tubers comprises a wide range of physiological and biochemical processes. The status and duration of dormancy depend on the genetic background, tuber's development stage, environmental conditions and operations during tuber's growth and storage. Abscisic acid and ethylene maintain the dormancy of the tuber. While gibberellins, cytokines, and indole acetic acid stimulate sprouting of tubers. Most studies on the dormancy of the tubers and the sprouting are very old and do not explain the mechanisms of dormancy regulation. Accordingly, we conducted this study with the aim of clarifying the mechanism of regulating the dormancy of potato tubers. Note:In this article we have relied mainly on some articles, (specially: CIP, 1989; Aksenova et al., 2013; Muthoni et al., 2014), which are mentioned in the references. So that they are linked, reformulated and developed in order to enrich the subject, which is of utmost importance to both farmers and researchers alike, and we hope that we have succeeded in reaching the desired goal.