Cancer has been the most threatening disease and it is the only disease which has 100 types in it. This disease has killed millions of people all over the world every year. There have been loads of Anti cancer drugs which are being introduced which would help in treating cancer patients. Melphalan, methotexate, cisplatin has been commonly used in chemotherapy for varied types of cancers. One of those few anti cancer drugs which are rarely used is Bleomycin. There has been lot of research developments being done and various drug interactions being conducted on this drug. This review article discusses about all those research developments and drug interactions conducted and also we would analyze the efficacy of this drug in providing better drug action to treat the patients. This drug in combination with Cisplatin and Etoposide would help in treatment of Non-seminomatous germ cell tumours (NSGCT).According to another study this drug also induces Pulmonary fibrosis is independent of eosinophils. Another study helps in evaluating the action of Bleomycin which may cause histological, immunohistochemical and biochemical changes in the pulmonary alveoli of adult male albino rats after it’s administration. One more study states that Bleomycin has better efficacy in drug action when it is administered in oil emulsion than that of W/O emulsion. Another study helps in assessing the sustained delivery and enhanced efficacy of pirfenidone-loaded nano particles after intra tracheal instillation.