Punica granatum L., commonly known as the pomegranate, is a fruit-bearing plant native to Iran and belonging to the Punicaceae family. Characterized by its large, globular berries containing numerous seeds enveloped in a juicy, edible pulp, pomegranate has been employed for centuries in various cultures to prevent and treat a multitude of health disorders, including inflammation, diabetes, diarrhea, dysentery, and dental plaque. Aim of the Review: This review aims to provide an up-to-date, comprehensive overview of the chemical constituents, traditional uses, phytochemistry, pharmacology, and toxicology of Punica granatum L. Specifically, this review focuses on the potential exploitation of this species to treat diverse diseases and suggests future investigations. The increasing demand for complementary medicine has driven the search for effective alternative therapies that minimize adverse effects associated with conventional drugs. Pomegranate has garnered significant attention due to its remarkable nutritional and medicinal properties. In Mexico, the harvest and consumption of pomegranate have surged, driven by recent discoveries of phytochemical compounds exhibiting antioxidant, anti-inflammatory, and antiviral activities, with promising applications in the food industry.
