Nursing education thrives towards training nurses to enable them play their role in the professional health team to provide high quality services to society. This study was aimed at comparing the effect of Interactive and Traditional teaching strategies on Student Nurse’s Academic performance at Nursing Schools, Zamfara state. Quasi-experimental design of non equivalent was adopted with total of One hundred and twenty-nine students (129) recruited for the study. Purposive sampling technique was used access the participants for both study and control groups. Self-administered Questionnaire and Assessment test were used to collect data and all ethical consideration ensured throughout the study. Three (3) hypotheses were stated to guide the study and Inferential statistics with SPSS software version 26 was used for testing the hypotheses. Null hypotheses stated at alpha value of 0.05 was greater than P- values of 0.000 and 0.033 were rejected; relationship between interactive teaching strategy and Academic Performance of the student nurses found that calculated p value of 0.015 was below the 0.05 alpha level of significance and the correlation index value of 0.822 is higher than the critical r value of 0.235 at df 74 were rejected , and there was significant Mean difference in the Academic Performance of student nurses from School of Nursing Gusau and their counterparts from School of Nursing Kaura Namoda, with the calculated p value of 0.000 is lower than the 0.05 alpha level of significance and the computed t value of 6.219 is greater than the 1.96 t critical at df 127.The research findings revealed the importance of interactive teaching strategies using Flipped Classroom and Fish bowl in increases students’ acquisition of skills, knowledge and developing them as holistic individuals. Use of flipped classroom and fish bowl resulted in better learning outcomes, students’ retention of knowledge and reflective practice, compared to the use of traditional learning method alone. Based on the findings of the study, It was recommended that there is need to emphasize and implement varying interactive teaching strategies and assessments, towards improved academic performance of students’ in Nursing institutions in Zamfara state.