Background: Swimmer’s shoulder pain is one of the most common injuries in elite swimmers; it is estimated that up to 65% of competitive swimmers will experience a problem with their shoulders at some point in their careers. In general, suffering a shoulder injury can affect the shoulder joint’s stability and mobility, and can affect the overall performance of swimmer athletes. Aim of the study: The study aimed at investigating the effect of Kinesio-taping on shoulder pain in the rehabilitation of adolescent swimmers with shoulder overuse injuries. Methods: Fifty adolescent swimmers of both genders, aged between 10 and 14 years and suffering from shoulder pain were selected and randomized into two equal groups (25 patients each). The first group received physical therapy program (i.e., strengthening exercises, stretching, and range of motion exercises) in addition to Kinesio-taping. The second group received only physical therapy program. After 12 sessions, the shoulder pain of both groups was assessed. Results: Kinesio-taping produced a significant reduction in shoulder pain and a significant increase in the Pain threshold of the study group compared to controls (p < 0.0001) after applying kinesio-tape in the study group compared with controls. Conclusion: Kinesio-taping is an effective therapeutic modality that can be added to rehabilitation programs for the sake of treating overuse injuries in adolescent competitive swimmers.