Background: Pressure ulcer is a serious problem that faces the medical team especially the plastic surgeon, physical therapists and other health care providers, Pressure ulcers also affect quality of life and lead to more frequent hospitalization. Aim of Study: To determine and compare effects of high voltage electrical stimulation and honey therapy on wound healing of lower limb pressure ulcers: Subjects and Methods: In the current study, efficacy of high voltage electrical stimulation versus honey therapy in the treatment of lower limb pressure ulcer were investigated. The study involved thirty patients suffering from lower limb pressure ulcer were selected randomly from INPATIENT Department of El Helal Hospital, their age ranged from 30 to 50 years. Patients who had psychological or mental disorders, cardiac disorders, any systemic disease that may interfere with study, blood or auto immune disease and diabetes mellitus were excluded from this study. These patients were divided randomly into two equal groups in number; Group A(High Voltage Electrical Stimulation Group): Fifteen patients with lower limb pressure ulcer who treated with HVES three times per week, for 24 sessions or until healing and regular wound care. Group B (Honey Therapy Group): Fifteen patients with lower limb pressure ulcer who treated with Honey Therapy three times per week, 24 sessions or until healing and regular wound care. Data obtained from both groups pre and post treatment regarding ultrasonographic ulcer depth (UUD) were statistically analyzed and compared. Results: Finding of the current study showed that there was significant decrease in (Ultrasonographic Ulcer Depth) UUD before and after treatment in both groups. There was no significant difference in the UUD between the group A (High Voltage Electrical Stimulation Group) and group B (Honey Therapy Group) post treatment. Conclusion: Application of High Voltage Electrical Stimulation (HVES) and Honey therapy in the treatment of lower limb pressure ulcers had a valuable healing effect. But there was no significant difference in the ultrasonographic ulcer depth (UUD) between group A (High Voltage Electrical Stimulation) and group B (Honey therapy) post treatment.