This descriptive correlational study investigated the influence of self-directed learning on academic adjustment among level I and II student nurses studying in a private university practicing a student-centered learning approach. Results revealed that student nurse respondents demonstrated stage 3 self-directed learning and need teacher facilitation for learning. Moreover, amidst generally poor internet connectivity, they have good adjustment academically in online education in the COVID 19 pandemic. Surprisingly, study results refute available literature that self-directed learning insignificant influences academic adjustment among level I and II student nurses.