Partially edentulous patients with challenging conditions like abused ridges, allergy to denture resins, undercuts due to angulated remaining teeth, cancerous lesions and cleft palate pose a great challenge for the fabrication of a successful removable partial denture. In such cases flexible dentures offer a comfortable and affordable option. It was a long thought that removable partial dentures had to be rigid but with innovation of flexible dentures, flexibility combined with strength and light weight provides total comfort and great looks. This article is an effort to review the various commercially available flexible denture base materials, a case presentation and highlights the indications and special instructions in wearing and maintenance of the same.