Introduction: This research assessed the perspective of the populace of Yenagoa metropolis on the efficacy of hand washing in reducing the spread of COVID-19 pandemic in Yenagoa metropolis. The objectives of this study were to examine the level of COVID-19 disease and investigate the efficacy of handwashing in reducing the spread of the diseases in Bayelsa State, Nigeria. This study design adopted the survey of Four hundred (400) randomly selected respondent with the aid of a well-structured questionnaire. Results showed that the level of COVID-19 disease in Yenagoa metropolis was low.Respondents strongly agreed that handwashing is effective in reducing the spread of COVID-19 was 65.32%. Consequent upon these findings, hand washing and other preventive measures should be sustained in reducing the spread of COVID-19.