Local drug delivery using chitosan microspheres – A review of literature

Background: Drug discovery is the process by which therapeutic agents are identified and developed while drug delivery refers to the processes and technologies employed to provide vehicles through which therapeutic agents are administered to patients ensuring safety, efficacy, and quality. Synthetic materials were favoured against natural materials due to challenges of standardization and extensive characterization required for natural materials. Objectives: Purpose of the study is to review the application of chitosan as a nano particle and its significance as a local drug delivery system. Methodology: The search study for the review paper is based on current literature having 15 articles which has been beneficial in title and research work done on local drug delivery. Results: This is a detailed literature review so the results will be in terms of the work done as discussed in review of literature. Conclusion: This paper reviews the structural characteristics and various synthesis methods used to produce chitosan nanoparticles and nanostructures, such as ionic gelation, micro emulsion, polyelectrolyte complexing, emulsification solvent diffusion, and the reverse micellar method. Various characterization techniques and analyses are also discussed.