Background: Acne vulgaris (AV) is a skin disorder that most often encountered, nearly 80% of teenagers and young adults had suffered from AV, its pathogenesis is not clear, but some studies have shown that dihydrotestosterone (DHT) is the androgen that is most responsible, especially in women, there is a correlation between DHT by the number of lesions. Soy tempeh contains soy isoflavones with the active component genistein, daidzein and glycitein, consumption in Asian countries four times more than in western countries, with the average of 24-45 mg per day. Soy isoflavones play a role in the metabolism of androgens, which inhibit the enzyme 3SS-hydroxysteroid dehydrogenase (3SS-HSD), 17ß-hydroxysteroid dehydrogenase (17ß-HSD) and 5α-reductase, whereas as antiinflammatory, which inhibits pro-inflammatory cytokines. The purpose of this study demonstrate the effect of soy tempeh on AV lesions in female patients. Methods: This study is a clinical study design with randomized pretest-posttest control group design, with 25 samples were randomized into 5 groups: soy tempeh 100 gr, 200 gr, 300 gr, 400 gr, and placebo, for 4 weeks, conducted a double-blind manner. Results: The study found differences in the mean total AV lesions before treatment among the five groups (p : 0.259) or not significant (p>0.05), whereas after treatment (p : 0.001) or significant (p<0.05). Differences decrease in the mean total AV lesion before and after the inter-group obtained soy tempeh 400 gr group (p < 0.05 ), while the placebo, 100 gr, 200 gr, 300 gr not significant (p>0.05), and the difference in total lesion AV delta (p:0.001) or significant (p<0.05). Conclusion: This study of soy tempeh supplementation 400 gr/day can lower total AV lesion.
