At least 40% of the world's population spends their time in places where levels of noise and vibration harmful to health prevail, also the study on the interior of vehicles indicates a significant value of specific descriptors of discomfort induced by noise and vibration. These parameters must comply with the regulations in force, and which appeal to the concept of reliability in systems that ensure the living conditions of passengers. The present paper aims to analyze the specific descriptive factors of vibrations and noise in vehicles with the aim of preliminary cumulative estimation of the global impact due to them on the human body, together with the selection of the best available techniques, with the aim of making contributions to the further mitigation of the impact of noise and potential vibrations on passengers, as well as the implementation of a strategy to improve the level of comfort.